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Long-term researches and monitoring of large contingents of practically healthy workers and employees revealed several important characteristics of the production processes characterized by unfavorable job conditions and work shifts higher numerical values of permanent and temporary disablement, high employee turnover and nervous-emotional tension, and lower general work capacity. The conducted psycho-physiological research and examinations demonstrated that the normal homeostatic balance of the organism is replaced by a new heterostatic balance. This, in turn, reveals overstress and depletion of adaptation reserves. What is typical of this heterostatic balance is that the psycho-physiological "cost" of the adequate adaptation to the work environment is increased. This results in objective changes in a large class of functions and bio-constants. We discovered that in terms of the vegetative system, this condition is reflected by a chronic increase of activity of the sympathicus part of the vegetative nervous system in a new direction toward unjustified "ergotropic" adjustment of the system (even in periods of complete rest). This leads to the conclusion that the chronically increased ergotropic status in rest is a biological indicator of the NAD.

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